Product Name :
2-Amino-8-hydroxyquinoline (CAS 70125-16-5)
Synonym :
2-Aminoquinolin-8-ol
Application :
CAS:
70125-16-5
Purity:
≥98%
Molecular Weight:
160.17
Formula :
C9H8N2O
Physical state:
Solid
solubility :
Soluble in water (partly), DMSO, and acetone.
Shipping Condition :
Store at -20° C
Melting point:
157-160° C
SMILES:
C1=CC2=C(C(=C1)O)N=C(C=C2)N
References:
:Investigating the activity spectrum for ring-substituted 8-hydroxyquinolines. | Musiol, R., et al. 2010. Molecules. 15: 288-304. PMID: 20110891Identifying chelators for metalloprotein inhibitors using a fragment-based approach. | Jacobsen, JA., et al. 2011. J Med Chem. 54: 591-602. PMID: 21189019Screening a fragment cocktail library using ultrafiltration. | Shibata, S., et al. 2011. Anal Bioanal Chem. 401: 1585-91. PMID: 21750879In silico design of small molecule inhibitors of CDK9/cyclin T1 interaction. | Randjelovic, J., et al. 2014. J Mol Graph Model.1135283-50-9 site 50: 100-12.661487-17-8 custom synthesis PMID: 24769691Effects of 2-amino-8-hydroxyquinoline interaction on the conformation of physiological isomers of human serum albumin.PMID:33545222 | Shiriskar, SM., et al. 2015. Eur Biophys J. 44: 193-205. PMID: 25761396Overview of CDK9 as a target in cancer research. | Morales, F. and Giordano, A. 2016. Cell Cycle. 15: 519-27. PMID: 26766294Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays. | Bremer, PT., et al. 2017. J Med Chem. 60: 338-348. PMID: 27966961Antileishmanial activity of synthetic analogs of the naturally occurring quinolone alkaloid N-methyl-8-methoxyflindersin. | Torres Suarez, E., et al. 2020. PLoS One. 15: e0243392. PMID: 33370295Targeting Protein-Protein Interactions to Inhibit Cyclin-Dependent Kinases. | Klein, M. 2023. Pharmaceuticals (Basel). 16: PMID: 37111276