Product Name :
20-HETE (CAS 79551-86-3)
Synonym :
20-hydroxy Arachidonic Acid
Application :
CAS: 79551-86-3. MW: 320.50. MF: C20H32O3.
CAS:
79551-86-3
Purity:
Molecular Weight:
320.50
Formula :
C20H32O3
Physical state:
Liquid
solubility :
Soluble in ethanol, DMSO, DMF, PBS (pH 7.2) (≥ 0.8 mg/ml), and 0.1 M Na2CO3 (2 mg/ml).
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
C(CC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)O)CCO
References:
:20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. | Kaduce, TL., et al. 2004. J Biol Chem. 279: 2648-56. PMID: 1461245120-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma. | Fang, X., et al. 2007. Prostaglandins Other Lipid Mediat. 82: 175-84. PMID: 17164145Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. | Fernandez, MM., et al. 2012. Eur J Pharmacol. 686: 97-103. PMID: 2257552420-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis. | Wang, J., et al. 2015. Am J Physiol Heart Circ Physiol. 308: H1359-67. PMID: 25820395Identification of novel CYP4F2 genetic variants exhibiting decreased catalytic activity in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). | Kim, WY., et al. 2018. Prostaglandins Leukot Essent Fatty Acids. 131: 6-13. PMID: 2962804920-HETE: Hypertension and Beyond. | Roman, RJ. and Fan, F. 2018. Hypertension. 72: 12-18. PMID: 29760152Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension. | Costa, TJ., et al. 2018. Front Physiol. 9: 490. PMID: 29867542Conflicting roles of 20-HETE in hypertension and renal end organ damage.(2-Cyclopropylpyridin-4-yl)boronic acid Chemical name | Zhang, C.Formula of 21950-36-7 , et al.PMID:33499717 2018. Eur J Pharmacol. 833: 190-200. PMID: 29886242The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury. | Zhang, X., et al. 2018. Prostaglandins Other Lipid Mediat. 137: 63-68. PMID: 3004176820-HETE in the regulation of vascular and cardiac function. | Rocic, P. and Schwartzman, ML. 2018. Pharmacol Ther. 192: 74-87. PMID: 3004870720-HETE Inhibition by HET0016 Decreases the Blood-Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury. | Lu, L., et al. 2018. Front Aging Neurosci. 10: 207. PMID: 30061822Inhibition of 20-hydroxyeicosatetraenoic acid (20-HETE) glucuronidation by non-steroidal anti-inflammatory drugs in human liver microsomes and recombinant UDP-glucuronosyltransferase enzymes. | Jarrar, YB., et al. 2020. Prostaglandins Leukot Essent Fatty Acids. 153: 102055. PMID: 3199997820-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin. | Hamers, A., et al. 2022. Br J Pharmacol. 179: 1450-1469. PMID: 34755897Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. | Kawamura, M., et al. 2022. J Med Chem. 65: 14599-14613. PMID: 36318660